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On tableting machine works
The punch and the die pressure in the compression process by the
large common bearing steel (such as crl5 etc.) production, and
heat-treated to increase its hardness.
Many types of punch, punch
shape depends on the tablet desired shape. Press die structural shape
can be divided into round, shaped (including polygons and curved); shape
cross-section with a flat punch shape, bevel-shaped, shallow concave,
deep concave and integrated shape. Cylinder-shaped tablets planar,
bevel-shaped punch for pressing flat, shallow concave to suppress
biconvex tablets, deep concave mainly used to suppress coated tablet
chip, integrated shaped mainly used to suppress profiled sheet form. In
order to facilitate the identification and taking drugs in the end face
of the die can also engrave the name of the drug, dosage and vertical
and horizontal lines and other signs. Suppression of different doses of
the tablet, you should choose the appropriate size of the die.
Operation (2) tableting machine tableting machine operation can be divided into the following steps:
①
undershoot punch site (its working position facing up) in the Central
die hole extends into the lower die hole, seal the hole in the bottom of
the mold;
② use Gacko in the die hole is filled to the drug;
③
punch punch on the site (its working position down) from falling into
the upper hole in the mold die hole, stroke and certain downside, the
powder into tablets;
④ enhance punch out the holes undershoot rise to the top of the tablet in the die hole, to complete a tabletting process;
⑤ rushed down to the next place, ready for the next fill.
(3) tablet tablets principle mechanism
①
dose control. Tablets have various requirements of different doses, the
dose is regulated by a large selection of different diameter punch die
to be achieved, if the diameter of 6mm, 8mm, 11.5mm, 12mm, etc. punch.
After choosing the size of the die, the dose is regulated by a slight
adjustment of the lower punch inserted into the die hole depth, thereby
changing the effective length of the back of the die hole, adjust the
volume of the mold fill hole drugs. Therefore, in the tableting machine
under the regulation should have a punch hole in the mold of the
original location of the institution to meet the requirements of a dose
adjustment. Because of differences in the specific volume of the total
batch preparation of different powders, such adjustment is necessary
function.
In the dose control, operation principle feeder also
has a considerable impact, such as particles of the drug are relying on
self-respect, freedom rolled into the hole in the mold, its loading
situation is more loose. If using multiple compulsive way into the
environment, the die hole will be filled with more drugs, filling the
situation is more dense.
② tablet thickness and compaction control.
Dose is determined according to the pharmacopoeia of prescription and
can not be changed. For storage, preservation and disintegration time
requirements, tableting pressure on certain dose is also a requirement,
it will also affect the actual thickness and appearance of the tablets.
Tabletting pressure regulation is essential. This is accomplished by
adjusting the hole punch in the die in an amount to achieve the
downlink. Some compression tableting machine in the process will not
only be on the red downward movement, but also to have a rush of action
for the next, by the relative movement of the upper and lower punch
tableting together to complete the process. But mostly the pressure
regulator to achieve controlled by a pressure regulator and the
regulator body washed downstream volume.
